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Know more about the sickle cell test including the sickle cell disease test cost, what causes sickle cell disease, sickle cell disease symptoms, treatment of sickle cell anemia, test procedure & risks.
Cost of Sickle Cell Test in the US

According to the Sickle Cell Disease Foundation, about 90,000 individuals are living with sickle cell anemia in the U.S. with 10% of the population at risk for the disease. So we highly recommend everyone who experiences the symptoms of sickle cell disease or are at a risk for the disease to get tested for sickle cell anemia test.

The article below covers all the significant topics related to sickle cell blood test such as sickle cell test cost, what is sickle cell disease, sickle cell disease symptoms, sickle cell trait testing, preparation, risks, and how to get tested for sickle cell disease.

  1. Sickle Cell test cost.
  2. What is a sickle cell test?
  3. What is sickle cell disease?
  4. What is a sick cell trait?
  5. Types of sickle cell disease.
  6. Sickle cell symptoms.
  7. Who should get tested for sickle cell test?
  8. How is the sickle cell test done?
  9. Is there any preparation required before the test?
  10. Are there any risks in the test?
  11. What does the test result mean?
  12. Sickle cell anemia treatment.
  13. What are the complications of sickle cell anemia?
  14. How to prevent sickle cell anemia?
  15. Providers Locations.

For our readers, who are very much interested in knowing the sickle cell test cost beforehand, we would like to begin with that section.

How much does the sickle cell test cost?

Sickle cell test cost ranges between $49 and $54 in different labs and facilities across the U.S. No prior appointment is required. Compare the price, order your test online and visit the nearest lab during lab business hours. Complete the procedure and get the results in your email in 2 to 3 business days. Doctor consultation is also available for further treatment or any kind of medical advice.

The following table shows the cost of sickle cell test at 2 of our partner laboratories (CLIA – Certified) network located across the U.S.

Name of our Partner Labs

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  • Reports – 1 to 3 days
  • The entire U.S.
  • Required to visit the lab

Offer Price


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Personal Testing Lab

  • Reports – 2 to 5 days
  • The entire U.S. except for New York, New Jersey & Rhode Island
  • Required to visit the lab

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Sickle cell test cost with insurance

Most of the health insurance policies in the U.S. cover the cost of the sickle cell test. However, the coverage offered by private health insurance companies and national health insurance programs like Medicare and Medicaid varies widely. So we recommend you to check the coverage of your health insurance plan before getting tested for sickle cell disease.

Our sickle cell testing providers do not accept any kind of health insurance plan. But, on request, they can provide you with an itemized receipt containing all the details like the name and code of the test, and CPT code that is necessary for insurance reimbursement purposes.

What is Sickle Cell Anemia
Sickle Cell Disease and its Symptoms

What is a sickle cell test?

A sickle cell test is a simple blood test that checks for hemoglobin S – the defective form of hemoglobin that causes sickle cell anemia. It is done to evaluate whether you have sickle cell disease or sickle cell trait. The sickle cell blood test is a part of routine newborn screening. However, it can also be performed on older children and adults if necessary.

What is sickle cell disease?

Red blood cells are very important as they carry oxygen throughout the body. The sickle cell disease is named for the C-shaped farming tool called sickle as the sickle cells are C-shaped and resemble a crescent moon, affecting the hemoglobin of the red blood cells. Sickle cells become hard and sticky and they tend to increase the risk for blood clots. These cells also die early resulting in the shortage of red blood cells.

There are two conditions that can cause sickle cell anemia namely sickle cell disease and sickle cell trait.

What is sickle cell trait?

Sickle cell trait is an inherited blood disorder that causes your body to produce abnormally shaped red blood cells.  Generally, in sickle cell trait, the child which inherits the sickle cell mutation gene from the parent’s is not said to be affected by the sickle cell disease. This defective gene can be passed to their future generations, resulting in sickle cell trait.

Sickle cell disease vs. sickle cell trait

In sickle cell disease, an individual has two abnormal hemoglobin S genes that cause the disease. An individual who has sickle cell trait have only one of the abnormal genes that might be passed on through either of his/her mother or father. People with sickle cell traits show mild or do not show any symptoms of sickle cell disease and they can never have sickle cell disease but they can pass it to their children.

Types of sickle cell disease

There are different types of sickle cell disease based on the specific type of abnormal hemoglobin you have. They are

  • Hemoglobin SS (most severe type)
  • Hemoglobin SC (mild type)
  • Hemoglobin Sβ thalassemia
  • Hemoglobin SD
  • Hemoglobin SE
  • Hemoglobin SO

Sickle cell symptoms

Sickle cell disease causes various symptoms. The following are some of the sickle cell symptoms

  • Fatigue caused by anemia
  • Shortness of breath
  • Frequent coughing
  • Yellowing of the skin
  • Recurrent of pain that is caused by blocked blood flow
  • Swelling in the hands and feet
  • Problems in the vision
  • Delayed growth
  • Frequent infections

Who should get tested for sickle cell test?

People with the following conditions should get tested for a sickle cell test.

  • Newborn babies as a part of routine newborn screening
  • Immigrants who haven’t been tested in their home countries
  • People who experience the symptoms of sickle cell disease
  • Pregnant women to know if they are a sickle cell carrier

How is the sickle cell test done?

The sickle cell test is done using the blood specimen.

During this test, a lab technician or a phlebotomist will cleanse the area to be injected with an antiseptic and wrap an elastic band around the upper arm to make the vein visible and swell with blood. He/she then injects a needle to draw a sample of blood and collects the blood sample in a test tube. After the blood is drawn, he/she covers the injected area with a band-aid or a cotton ball to stop bleeding. The collected blood sample is then sent to the lab for further analysis.

In the case of infants and children, the blood sample will be taken from the heel or finger with the help of a sharp tool called a lancet.

It takes less than 5 to 10 minutes to perform this test.

Is there any preparation required before the test?

There is no special preparation required for the sickle cell test. But physicians recommend not to take a sickle cell test up to 90 days after receiving a blood transfusion as it may influence the test results and lead to an inaccurate diagnosis.

Are there any risks in the test?

There are no possible complications in the sickle cell blood test. After the blood sample is drawn, you might feel dizziness, slight pain, bruise, or redness in the injected spot for a very little period.

What does the test result mean?

The sickle cell blood test looks for the abnormal hemoglobin S in the blood. If the test result is negative, then it means your hemoglobin is normal. If the test result is positive, then it shows that you have sickle cell disease or sickle cell trait.

If the test is positive, your physician will order another test called hemoglobin electrophoresis to distinguish between sickle cell disease and sickle cell trait.

Sickle cell treatments

Sickle cell anemia treatments are of three protocols, they are 

Bone marrow transplant :

It is also generally known as stem cell transplant and it is the only potential cure for sickle cell anemia. This type of diagnosis is generally recommended for people younger than 16 years of age.

Medications :

Medications such as antibiotic penicillin, hydroxyurea, and other pain-relieving pharmaceutical drugs help in reducing the pain and preventing complications.

Blood transfusions :

Blood transfusion increases the number of normal red blood cells in circulation and helps to relieve anemia. It can also be used to diagnose other complications of sickle cell anemia.

Other experimental treatments include gene therapy and drugs to boost fetal hemoglobin.

What are the complications of sickle cell anemia?

Sickle cell anemia can cause severe complications such as

  • Stroke
  • Acute chest syndrome (chest pain, fever, and difficulty in breathing)
  • Pulmonary hypertension (high blood pressure in the lungs)
  • Organ damage due to deprivation of oxygen-rich blood
  • Blindness
  • Leg ulcers (open sores on the legs)
  • Gallstones
  • Priapism (painful and long-lasting erections due to the blockage of blood vessels in the penis)
Complications of Sickle Cell - DxSaver
Complications of Sickle Cell Disease

How to prevent sickle cell anemia?

There are no possible ways to prevent sickle cell anemia. However, if you are a carrier of sickle cell trait seeing a genetic counselor before trying to conceive can help you in understanding the risk of having a child with sickle cell anemia. The counselor will also help you with available treatments and other reproductive options.

Providers Locations

The sickle cell test can be done in any of the following locations by visiting the lab near you. To know the sickle cell test cost, refer to the first section of the article.

  • Alabama
  • Alaska
  • Arizona
  • Arkansas
  • California
  • Colorado
  • Connecticut
  • Delaware
  • Florida
  • Hawaii
  • Georgia
  • Idaho
  • Illinois
  • Indiana
  • Iowa
  • Kansas
  • Kentucky
  • Louisiana
  • Maine
  • Michigan
  • Minnesota
  • Mississippi
  • Missouri
  • Montana
  • Nebraska
  • Nevada
  • New Hampshire
  • New Mexico
  • North Carolina
  • North Dakota
  • Oklahoma
  • Oregon
  • Pennsylvania
  • Puerto Rico
  • South Carolina
  • South Dakota
  • Tennessee
  • Texas
  • Utah
  • Vermont
  • Virginia
  • Washington
  • West Virginia
  • Wisconsin
  • Wyoming

Frequently Asked Questions

Will insurance cover my testing cost?

No, insurance will not be covered in the billing. However, they will provide you a receipt for insurance reimbursement purposes.

How should I book my appointment?

You can choose the most suitable provider from above and make an appointment by following the instructions mentioned by them.

Can I cancel my lab test order?

Yes, you can cancel your lab test order anytime before your testing. A refund will be initiated after deducting the cancellation fee. However, cancellation is at the discretion of the provider.

Do the providers offer result interpretations?

Yes, a few providers may provide doctor consultation who will take you through the results and provide clarification if needed.

How do I receive my report?

To ensure your privacy, the test report will be mailed to you by the provider.

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